PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection
Identifieur interne : 000A32 ( Main/Exploration ); précédent : 000A31; suivant : 000A33PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection
Auteurs : Qiang Wang [République populaire de Chine] ; Shijian Zhang [République populaire de Chine] ; Hongbing Jiang [République populaire de Chine] ; Jinlan Wang [République populaire de Chine] ; Leiyun Weng [République populaire de Chine] ; Yingying Mao [République populaire de Chine] ; Satoshi Sekiguchi [Japon] ; Fumihiko Yasui [Japon] ; Michinori Kohara [Japon] ; Philippe Buchy [Cambodge] ; Vincent Deubel [Cambodge] ; Ke Xu [République populaire de Chine] ; Bing Sun [République populaire de Chine] ; Tetsuya Toyoda [République populaire de Chine, Japon]Source :
- Virology Journal [ 1743-422X ] ; 2012.
Abstract
Although gene exchange is not likely to occur freely, reassortment between the H5N1 highly pathogenic avian influenza virus (HPAIV) and currently circulating human viruses is a serious concern. The PA polymerase subunit of H5N1 HPAIV was recently reported to activate the influenza replicon activity.
The replicon activities of PR8 and WSN strains (H1N1) of influenza containing PA from HPAIV A/Cambodia/P0322095/2005 (H5N1) and the activity of the chimeric RNA polymerase were analyzed. A reassortant WSN virus containing the H5N1 Cambodia PA (C-PA) was then reconstituted and its growth in cells and pathogenicity in mice examined. The interferon promoter, TUNEL, and caspase 3, 8, and 9 activities of C-PA-infected cells were compared with those of WSN-infected cells.
The activity of the chimeric RNA polymerase was slightly higher than that of WSN, and C-PA replicated better than WSN in cells. However, the multi-step growth of C-PA and its pathogenicity in mice were lower than those of WSN. The interferon promoter, TUNEL, and caspase 3, 8, and 9 activities were strongly induced in early infection in C-PA-infected cells but not in WSN-infected cells.
Apoptosis and interferon were strongly induced early in C-PA infection, which protected the uninfected cells from expansion of viral infection. In this case, these classical host-virus interactions contributed to the attenuation of this strongly replicating virus.
Url:
DOI: 10.1186/1743-422X-9-106
PubMed: 22681768
PubMed Central: 3507744
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Checkpoint: 000697
- to stream Ncbi, to step Merge: 000773
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Le document en format XML
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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jinlan" sort="Wang, Jinlan" uniqKey="Wang J" first="Jinlan" last="Wang">Jinlan Wang</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Weng, Leiyun" sort="Weng, Leiyun" uniqKey="Weng L" first="Leiyun" last="Weng">Leiyun Weng</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Yingying" sort="Mao, Yingying" uniqKey="Mao Y" first="Yingying" last="Mao">Yingying Mao</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sekiguchi, Satoshi" sort="Sekiguchi, Satoshi" uniqKey="Sekiguchi S" first="Satoshi" last="Sekiguchi">Satoshi Sekiguchi</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name><affiliation wicri:level="1"><nlm:aff id="I6">Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Deubel, Vincent" sort="Deubel, Vincent" uniqKey="Deubel V" first="Vincent" last="Deubel">Vincent Deubel</name><affiliation wicri:level="1"><nlm:aff id="I6">Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><affiliation wicri:level="1"><nlm:aff id="I1">Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="I1">Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I7">Choju Medical Institute, Fukushimura Hospital, 19-14 Azanakayama, Noyori-cho, Toyohashi, Aichi, 441-8124, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Choju Medical Institute, Fukushimura Hospital, 19-14 Azanakayama, Noyori-cho, Toyohashi, Aichi, 441-8124</wicri:regionArea><wicri:noRegion>441-8124</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22681768</idno><idno type="pmc">3507744</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507744</idno><idno type="RBID">PMC:3507744</idno><idno type="doi">10.1186/1743-422X-9-106</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000598</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000598</idno><idno type="wicri:Area/Pmc/Curation">000598</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000598</idno><idno type="wicri:Area/Pmc/Checkpoint">000697</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000697</idno><idno type="wicri:Area/Ncbi/Merge">000773</idno><idno type="wicri:Area/Ncbi/Curation">000773</idno><idno type="wicri:Area/Ncbi/Checkpoint">000773</idno><idno type="wicri:Area/Main/Merge">000A32</idno><idno type="wicri:Area/Main/Curation">000A32</idno><idno type="wicri:Area/Main/Exploration">000A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection</title><author><name sortKey="Wang, Qiang" sort="Wang, Qiang" uniqKey="Wang Q" first="Qiang" last="Wang">Qiang Wang</name><affiliation wicri:level="1"><nlm:aff id="I1">Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shijian" sort="Zhang, Shijian" uniqKey="Zhang S" first="Shijian" last="Zhang">Shijian Zhang</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Shanghai Medical College of Fudan University, Yixueyuan Road 138, Shanghai, 200032, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Medical College of Fudan University, Yixueyuan Road 138, Shanghai, 200032</wicri:regionArea><wicri:noRegion>200032</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Roche R&D Center China LTD, 720 Cai Lun Road, Building 5, Pudong, Shanghai, 201203, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Roche R&D Center China LTD, 720 Cai Lun Road, Building 5, Pudong, Shanghai, 201203</wicri:regionArea><wicri:noRegion>201203</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Hongbing" sort="Jiang, Hongbing" uniqKey="Jiang H" first="Hongbing" last="Jiang">Hongbing Jiang</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jinlan" sort="Wang, Jinlan" uniqKey="Wang J" first="Jinlan" last="Wang">Jinlan Wang</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Weng, Leiyun" sort="Weng, Leiyun" uniqKey="Weng L" first="Leiyun" last="Weng">Leiyun Weng</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Yingying" sort="Mao, Yingying" uniqKey="Mao Y" first="Yingying" last="Mao">Yingying Mao</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sekiguchi, Satoshi" sort="Sekiguchi, Satoshi" uniqKey="Sekiguchi S" first="Satoshi" last="Sekiguchi">Satoshi Sekiguchi</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation></author><author><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name><affiliation wicri:level="1"><nlm:aff id="I6">Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Deubel, Vincent" sort="Deubel, Vincent" uniqKey="Deubel V" first="Vincent" last="Deubel">Vincent Deubel</name><affiliation wicri:level="1"><nlm:aff id="I6">Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Institut Pasteur in Cambodia, 5 Monivong Blvd, P.O. Box 983, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><affiliation wicri:level="1"><nlm:aff id="I1">Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="I1">Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Molecular Virology, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><affiliation wicri:level="1"><nlm:aff id="I2">Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Units of Viral Genome Regulation, the Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, 200025, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Biology, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8613</wicri:regionArea><wicri:noRegion>113-8613</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I7">Choju Medical Institute, Fukushimura Hospital, 19-14 Azanakayama, Noyori-cho, Toyohashi, Aichi, 441-8124, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Choju Medical Institute, Fukushimura Hospital, 19-14 Azanakayama, Noyori-cho, Toyohashi, Aichi, 441-8124</wicri:regionArea><wicri:noRegion>441-8124</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although gene exchange is not likely to occur freely, reassortment between the H5N1 highly pathogenic avian influenza virus (HPAIV) and currently circulating human viruses is a serious concern. The PA polymerase subunit of H5N1 HPAIV was recently reported to activate the influenza replicon activity.</p></sec><sec><title>Methods</title><p>The replicon activities of PR8 and WSN strains (H1N1) of influenza containing PA from HPAIV A/Cambodia/P0322095/2005 (H5N1) and the activity of the chimeric RNA polymerase were analyzed. A reassortant WSN virus containing the H5N1 Cambodia PA (C-PA) was then reconstituted and its growth in cells and pathogenicity in mice examined. The interferon promoter, TUNEL, and caspase 3, 8, and 9 activities of C-PA-infected cells were compared with those of WSN-infected cells.</p></sec><sec><title>Results</title><p>The activity of the chimeric RNA polymerase was slightly higher than that of WSN, and C-PA replicated better than WSN in cells. However, the multi-step growth of C-PA and its pathogenicity in mice were lower than those of WSN. The interferon promoter, TUNEL, and caspase 3, 8, and 9 activities were strongly induced in early infection in C-PA-infected cells but not in WSN-infected cells.</p></sec><sec><title>Conclusions</title><p>Apoptosis and interferon were strongly induced early in C-PA infection, which protected the uninfected cells from expansion of viral infection. 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Y">Y Fukuhara</name></author><author><name sortKey="Sato, M" uniqKey="Sato M">M Sato</name></author><author><name sortKey="Ozato, K" uniqKey="Ozato K">K Ozato</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T Fujita</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Cambodge</li><li>Japon</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Qiang" sort="Wang, Qiang" uniqKey="Wang Q" first="Qiang" last="Wang">Qiang Wang</name></noRegion><name sortKey="Jiang, Hongbing" sort="Jiang, Hongbing" uniqKey="Jiang H" first="Hongbing" last="Jiang">Hongbing Jiang</name><name sortKey="Mao, Yingying" sort="Mao, Yingying" uniqKey="Mao Y" first="Yingying" last="Mao">Yingying Mao</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><name sortKey="Wang, Jinlan" sort="Wang, Jinlan" uniqKey="Wang J" first="Jinlan" last="Wang">Jinlan Wang</name><name sortKey="Wang, Qiang" sort="Wang, Qiang" uniqKey="Wang Q" first="Qiang" last="Wang">Qiang Wang</name><name sortKey="Weng, Leiyun" sort="Weng, Leiyun" uniqKey="Weng L" first="Leiyun" last="Weng">Leiyun Weng</name><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><name sortKey="Zhang, Shijian" sort="Zhang, Shijian" uniqKey="Zhang S" first="Shijian" last="Zhang">Shijian Zhang</name><name sortKey="Zhang, Shijian" sort="Zhang, Shijian" uniqKey="Zhang S" first="Shijian" last="Zhang">Shijian Zhang</name><name sortKey="Zhang, Shijian" sort="Zhang, Shijian" uniqKey="Zhang S" first="Shijian" last="Zhang">Shijian Zhang</name></country><country name="Japon"><noRegion><name sortKey="Sekiguchi, Satoshi" sort="Sekiguchi, Satoshi" uniqKey="Sekiguchi S" first="Satoshi" last="Sekiguchi">Satoshi Sekiguchi</name></noRegion><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name></country><country name="Cambodge"><noRegion><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name></noRegion><name sortKey="Deubel, Vincent" sort="Deubel, Vincent" uniqKey="Deubel V" first="Vincent" last="Deubel">Vincent Deubel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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